Anavex Life Sciences Corp (AVXL)

[falconer66a]

The Mechanisms of Blarcamesine’s Alzheimer’s Therapy

falconer---"Worth a read."---care to comment on this recent post by Mayomobile ?? From where I sit very meaningful !!!!

Read the last two paragraphs. They summarize the important information.

https://www.linkedin.com/posts/jesse-silveira-1a366927b_alzheimer-lysosomal-acidification-activity-7303768912863653890-loM0/

In summary, blarcamesine modulates, properly facilitates the calcium transport involved in cellular functions in neurons. Aberrant calcium transport/availability compromises the cell-keeping maintenance functions that normally prohibit the deposit of the waste proteins that inhibit proper nerve physiology.

Malfunctioning nerves are at the heart of Alzheimer’s disease. Simply, without fully functioning calcium transport neurons can’t perform "autophagy," which means "self-eating;" the major cell-keeping process where the cell "eats" or destroys accumulated cellular waste chemicals.

Cell-keeping autophagy keeps cells functioning, keeps them from malfunctioning as they age. Blarcamesine activating the sigma-1 receptor causes the cell to properly transport calcium, which consequently facilitates all of the propitious downstream processes. With all of that, neurons can continue to function normally.

Many years ago, when I discovered Anavex and from what I understood about the company’s unique molecular biology I started accumulating my AVXL position (using only discretionary funds I could afford to lose). At the time, blarcamesine’s molecular and cell physiological mechanisms were not well known. For most, seemingly some cellular magic.

Not so today. There is abundant evidence telling how blarcamesine’s activation of the sigma-1 receptor protein is able to cause the good therapeutic outcomes in people with Alzheimer’s — and, how in the future, the drug will be able to delay or even prohibit the onset of the disease, when used prophylactically, as a disease preventative.

The European Medicines Agency now has in its hands all of the studies and data that show how blarcamesine works, the MOAs, mechanisms of action. Nothing at all magical. Just some phenomenal facilitation of normalized cellular physiology, unique to Anavex’s proprietary sigma-1 receptor molecules.