Anavex Life Sciences Corp (AVXL)

[XenaLives]

You must be kidding.....

1. Are there any STUDIES that show the connection of brain shrinkage to AD functional benefit? (Not anecdotal data, but serious studies). I doubt it.
2. Even if these studies exist -- are they for the similar parts of the brains, as AVXL's drug work?

This is basic science...

Brain atrophy is a loss of neurons that occurs in Alzheimer's disease and is a widely accepted biomarker for the disease. In Alzheimer's, brain atrophy is accelerated compared to the atrophy that occurs with age, even in people who are cognitively healthy. Alzheimer's disrupts the processes that are vital to neurons and their networks, including communication, metabolism, and repair. This damage can cause many neurons to stop functioning properly, lose connections with other neurons, and eventually die.

National Institute on Aging
What Happens to the Brain in Alzheimer's Disease?
Jan 19, 2024 — How does Alzheimer's affect the brain? The brain typically shrinks to some deg...

Alzheimer's Association
Brain Atrophy and B Vitamins - Alzheimer's Association
September 22, 2010. Brain atrophy involves the loss of neurons. Some degree of atrophy and...

ScienceDirect.com
Predicting brain atrophy from tau pathology: a summary of ...
Atrophy rates are higher in pre-symptomatic and symptomatic Alzheimer's patients than in h...
The medial temporal lobe (MTL) is the first region of the brain to show atrophy in Alzheimer's disease. Over time, there are four main patterns of atrophy in Alzheimer's disease:
Progressive hippocampal and cortical atrophy: 59% of patients
Progressive hippocampal atrophy only: 19% of patients
Progressive cortical atrophy only: 12% of patients
No atrophy in either region: 10% of patients
Symptoms of brain atrophy can vary depending on which part of the brain is damaged and can range from mild to severe. Some symptoms include:
Aphasia
Difficulty speaking or writing
Inability to understand the meaning of words
Dementia
Hallucinations
Loss of language
Memory problems
Mood and personality changes
Poor judgment
Seizures
This is for informational purposes only. For medical advice or diagnosis, consult a professional. Generative AI is experimental.

You don't have a clue when it comes to the science ... search this thread for the term "autophagy" and read the discussion.

You can also read this article:
https://www.nature.com/articles/s43587-021-00098-4