Revance Therapeutics Inc (RVNC)

[rock mountain]

Cell penetrating peptide: DAXXIFY is the only botulinum toxin with cell penetrating peptide technology (1, 6-10). On the RVNC website in the cervical dystonia chapter, one can find the latter statement. I never heard the claim of "cell penetration" before. The references after this statements are the prescription informations of Daxxi and of the other bot. toxins - not any article in a learned journal. Have I fallen asleep behind the wheeel - thus far the story of the adjuvant was its postive charge which thus allowed the toxin to remain close the negatively charged cell surface, allowing for better endocytosis. I never read anywhere that the adjuvant aids in cell penetration. Cell penetration from outside directly into the cytoplasm? Is this just a marketing message, keep it simple? For medical products any statement needs to be backed up with published facts - are there any? Anybody know? Thanks Rockmountain