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If I stop taking supplements for 6-8 hours I lose functional response...

If I don't take enough NAC I feel it immediately. I always have a stash in my purse.

It is possible that my loss of taste is both neurological and collagen related.

From AI -

Fluoroquinolones, a class of antibiotics that includes ciprofloxacin, levofloxacin, and moxifloxacin, can increase the risk of developing collagen-associated diseases. These diseases include: aortic aneurysm or aortic dissection, retinal detachment, and tendon disorders.

PubMed
Fluoroquinolone Use and the Risk of Collagen-Associated ...
Conclusions: Fluoroquinolone use incurs a risk of developing three collagen-associated diseases (aortic aneurysm or aortic dissection, retinal detachment, and tendon disorders). Patients at an increased risk of collagen-associated diseases should not use fluoroquinolones unless no other options are available.

Lippincott
Fluoroquinolones increase the risk of aortic aneurysm and di...
Dec 23, 2021 — [7,8] The fluoroquinolones class of antibiotics (e.g., ciprofloxacin, levofloxacin, moxifloxacin) has been used to treat a broad range of infections ranging from urinary tract infections to respiratory infections. Several observational trials have shown an association between the use of fluoroquinolones and the development of collagen-related adverse events including tendon rupture, retinal detachment, aortic aneurysm, or aortic dissection. [10–13] This was thought to be linked, in part to fluoroquinolone-related oxidative stress resulting in degenerative changes to the extracellular matrix components.
Fluoroquinolones may affect collagen synthesis or structure in the aortic wall by:
Chelating metal ions
Fluoroquinolones can bind to metal ions like calcium, magnesium, and aluminum, which are necessary for type 1 collagen synthesis.
Increasing matrix metalloproteinases
Fluoroquinolones can increase the expression of matrix metalloproteinases, which can degrade the extracellular matrix and degenerate the medial layer. This can lead to a reduction in collagen fibrils of types I and III, which make up most of the collagen in the aorta and Achilles tendons.
Patients who are at an increased risk of collagen-associated diseases should avoid fluoroquinolones unless other options are unavailable.
This is for informational purposes only. For medical advice or diagnosis, consult a professional. Generative AI is experimental.