Biotech Ideas

[XenaLives]

I disagree - if it's caused by antibiotics, treating it with more antibiotics (described as S.O.C. in most of the literature I found) seems like a dumb idea.

I read it again... it sounds like a more reasonable treatment method.

N-acetylcysteine (NAC) is an antioxidant that can help protect against the effects of Clostridium difficile (C. difficile) toxins. C. difficile is a bacterium that can cause antibiotic-associated diarrhea and pseudomembranous colitis. The majority of pathogenic strains of C. difficile secrete two large exotoxins, TcdA and TcdB, which can cause inflammation, tissue necrosis, and fluid secretion. NAC can help protect against the effects of these toxins in a few ways:

Reactive oxygen species (ROS)
NAC can reduce ROS levels, which can help prevent apoptosis and loss of viability in neuronal cells treated with toxin A. Chemical attenuation of ROS may be a viable strategy for protecting the colonic mucosa of patients with C. difficile infection (CDI).

Glutathione (GSH) levels
NAC can prevent the depletion of GSH levels in epithelial cells caused by C. difficile toxins. This depletion is important for the development and progression of cytopathology caused by the toxins. NAC can also prevent the toxins from causing rounding up and breakdown of the actin cytoskeleton.

also...

NAC prevents the oxidative imbalance induced by C. difficile toxins in epithelial cells. It is known that oxidative stress may be involved in several pathways leading to cellular retraction and rounding associated to the cytoskeletal rearrangement.Jun 18, 1999

https://www.sciencedirect.com/science/article/pii/S0014579399007061