Anavex Life Sciences Corp (AVXL)

[georgejjl]

APOE in Super-Seniors

"...We found that plasma p-tau181 is positively associated with APOE e4 carriership in resilient Super-Seniors > 85 years old without clinical dementia, diabetes, cardiovascular, or pulmonary disease. Therefore, APOE genotype should be considered when interpreting plasma p-tau181 regardless of clinical disease status...."

"...APOE e4 genotype modifies plasma p-tau181 concentration in seniors resilient to age-related clinical disease, suggesting that some Super-Seniors may have Alzheimer's disease pathology without progressing to cognitive decline...."

https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13804?campaign=wolearlyview

APOE e4 carriers are 2.4 times more frequent in the High AV2-73 concentration cohort compared to Low concentration cohort


See slides #15, #16 and #17

http://www.arianapharma.com/wp-content/uploads/2019/03/ANAVEX2-73_CTAD_2018_Presentation_v2.pdf

Good luck and GOD bless,