NorthWest Biotherapeutics Inc (NWBO)

[Johnni]

Thank you so much! I just read a few parts of the May 8 Nature Communications study (there is a link in the press release). The actual research work is quite old -- about a decade. Happily their current research is much farther ahead of what the journal article documents.

I seem to recall a talk Linda Liau gave in the last year or few in which she discussed adding the poly-ICLC and other adjuvant to a DC-Vax cocktail. She said the outcomes were promising, and the study went well far as it went, but also they noticed that the tumor cells often learned to fight back in a new way to get around the cocktail. So Liau's and Prins's lab added something more to the mix to address the new problem.

They are continuing through this process, and they might be up to at least four cocktail ingredients by now, but I don't really remember. I'm sure someone else here knows a lot more than I do.

They're also getting better at understanding and figuring out how to respond to the molecular mechanisms in the tumor and its environment.

As it is, I find the overall survival outcomes for the DC-Vax + poly-ICLC study to be pretty exciting, especially knowing that the lab is already progressing further along the path. Of course, what it means for NWBO is up for debate.