Anavex Life Sciences Corp (AVXL)

[XenaLives]

From Google AI...

Sigma-1 receptors (s-1R) are endoplasmic reticulum (ER) proteins that regulate neurotransmitter release and glutamate NMDA receptor function. They are involved in higher-order brain functions like learning, memory, and drug dependence.
s-1R receptors have a widespread modulatory role, including:
--Regulating the release of neurotransmitters like dopamine
--Modulating ion channels like NMDA receptors, K+ channels, and IP3 receptors
--Enhancing the function of N-methyl-d-aspartate receptors (NMDARs)
--Participating in neurotransmission, neuroprotection, and neuroinflammation

Because of their role in these processes, s-1R ligands have been proposed as potential treatments for:
--Amnesic and cognitive deficits
--Depression and anxiety
---Schizophrenia
--Analgesia
--Effects of drugs of abuse like cocaine and methamphetamine
--SARS-CoV-2 infection

s-1R receptors have been implicated in a number of diseases, including: HD, Depression, PBA, and Alzheimer's disease.