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Re: mrplmer post# 457603

Thursday, 04/25/2024 11:49:51 AM

Thursday, April 25, 2024 11:49:51 AM

Post# of 463122
But we already know it was significant...the Sept 2023 PR from Anavex (overseen by Dr Jin who has 25 years with FDA as a lead on AD trials) had ADAS COG with a p value of 0.026 i.e 2.26 in a 100 chance that the improvement was due to chance. The FDA draft guidance now states this is the end point they care most about now, not ADL as it's too difficult to show in early AD studies (though Missling did say ADL was trending in right direction in latest call).
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