NorthWest Biotherapeutics Inc (NWBO)

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Reminder: NWBIO February 6, 2024

“The special difficulty involved in developing the Flaskworks machine was that, unlike other cell types, the dendritic cells tightly adhere to the surface of the culture vessel (similar to barnacles). Extracting them from inside the culture vessel without damaging the cells or reducing the yield of doses was extremely challenging. Other cells (including T cells) are generally cultured suspended in liquid in a bag, which makes it much easier to move them through processes. Many companies have developed or are developing machines to handle such other cell types – but not adherent cells. [Note: Flaskworks solved this challenge]

The tight adherence of dendritic cells is essential for 3 main reasons:

(a) to isolate the specific desired cell population and remove others,

(b) to assess the health of the patient’s immune cells (if the cells do not adhere tightly, they are likely not healthy) and

(c) to start the activation of the dendritic cells (the adherence triggers the start of activation).”