NorthWest Biotherapeutics Inc (NWBO)

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Dr. Liau mentioned a lot about transcriptomic study in her publications. How is transcriptomic study related to cancer study? ChatGPT gave the reply.

https://scholar.google.com/scholar?hl=en&as_sdt=0%2C44&q=Linda+Liau+%2B+Transcriptomic&btnG=

Cellular and transcriptional immune responses induced by neoadjuvant PD-1 blockade in glioblastoma patients
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE154795

Transcriptomic characterization of GBM tumor and vascular cells and IBSP on patient-delived gliomasphere culture
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE186932

Transcriptomic studies play several important roles in cancer treatment:

Identification of Biomarkers: Transcriptomic analysis can identify specific RNA molecules (such as messenger RNA or non-coding RNA) that are differentially expressed in cancer cells compared to normal cells. These differentially expressed genes can serve as biomarkers for early cancer detection, prognosis prediction, and monitoring treatment response. Biomarkers identified through transcriptomic studies can help tailor treatment plans to individual patients, leading to more personalized and effective therapies.

Understanding Cancer Biology: Transcriptomic studies provide insights into the underlying molecular mechanisms driving cancer development and progression. By analyzing gene expression patterns in cancer cells, researchers can identify dysregulated signaling pathways, molecular drivers of oncogenesis, and potential therapeutic targets. This knowledge enhances our understanding of cancer biology and informs the development of targeted therapies designed to disrupt specific molecular pathways involved in tumorigenesis.

Predicting Drug Response: Transcriptomic profiling can be used to predict how cancer cells will respond to different therapeutic agents. By analyzing gene expression signatures associated with drug sensitivity or resistance, researchers can identify patients who are likely to benefit from particular treatments and those who may not respond or may develop resistance. This information enables oncologists to make more informed decisions when selecting treatment options for individual patients, maximizing therapeutic efficacy while minimizing adverse effects.

Drug Discovery and Development: Transcriptomic studies provide valuable data for drug discovery and development efforts. By identifying genes that are aberrantly expressed in cancer cells, researchers can prioritize novel drug targets for further investigation. Additionally, transcriptomic profiling can be used to screen potential therapeutic compounds for their ability to modulate gene expression patterns associated with cancer progression. This approach facilitates the identification of new anticancer drugs and the optimization of existing therapies to improve patient outcomes.

Overall, transcriptomic studies play a crucial role in advancing our understanding of cancer biology, guiding treatment decisions, and driving the development of innovative therapies to combat this complex disease.