NorthWest Biotherapeutics Inc (NWBO)

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https://www.abbvie.com/science/areas-of-focus/oncology.html

People have dedicated their lives to finding a cure.

Building on expertise to tackle the toughest cancers

Our scientific research has led to critical discoveries in the treatment of blood cancer. Now we’re expanding our knowledge to help treat solid tumors, which represent more than 90% of cancers that affect people.

We leverage our deep understanding of human biology and cutting-edge research technologies to find new ways to improve the lives of people with cancer.
Research interests

We focus on creating targeted medicines that either impede the reproduction of cancer cells or enable their death. We achieve this through immuno-oncology approaches, tumor antigen targeting, and taking advantage of specific tumor dependencies. Our research interests include:

Identifying and targeting mechanisms that allow tumor cells to proliferate and survive, including under-explored forms of regulated cell death, such as necroptosis and ferroptosis

Investigating how to re-energize T cells so that they can retain their fitness and continue to destroy tumor cells

Advancing the use of Antibody Drug Conjugates (ADCs) to target and deliver potent toxins and targeted agents directly to cancer cells

Creating new technologies to improve the efficacy of bispecific biologics in treating both solid tumors and blood cancers, enabling the development of therapies with highly targeted potential

Innovating in the field of targeted protein degradation by designing protein degraders that bind to a protein of interest and trigger its proteasomal degradation

Developing CAR-T cell therapies that attack cancers with healthy donor immune cells engineered to target and kill tumor cells while being resistant to host immune system rejection

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