NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

Continued: Car-t case study article.

“They are counting tumor “stabilization” to extend their 7.5 month “dramatic” response claim.” flipper

They are wrong. Tumors two and three had recurrences immediately adjacent to each site in tumors six and seven 45 days after starting resection and car-t treatment.

Only tumor 1 remained “stable”, after the second resection, by their own admission.** That is not dramatic in the least, and 1 is definitionally not stable, when tumor recurrence is happening elsewhere in the cns.

And yet they add this time in order to claim a 7.5 month response.

**

During the six weekly intracavitary infusions (cycles 1 through 6) (Figure 1A), the treated tumor in the temporal–occipital region (tumor 1) remained stable for more than 45 days after surgery without evidence of disease progression (Figure 1B). However, MRI revealed that nonresected tumors in the left temporal lobe (tumors 4 and 5) and new tumors (tumors 6 and 7) near the resected lesions 2 and 3 were progressing (Figure 1B). In addition, new metastatic lesions in the spine causing leg numbness, including one large tumor that was 18 mm in diameter and several smaller tumors (=4 mm), were detected (Figure 2C, and Fig.