I'd be 93 then, I really wouldn't mind if we're slowing our rate of growth if NWBO is still around then, and so am I. Even if we only had 10 years of exclusivity, I suspect that anyone with a reasonable investment in NWBO who hangs on to it will be wealthy. I have more than a reasonable investment, but I think many have much more than me.
Out of curiosity, does anyone think that even if more tumor may be surgically removed the vaccine may be more effective if more of the tumor is left in the patient, as long as sufficient tumor is taken to make al the vaccine they'd want to make. I know it sounds crazy, but if the tumor becomes the host for additional T-cells perhaps more of it in the patient might work better.
Many years ago IMGN's first drugs were not humanized conjugate of ricin, it was a large molecule and patients were becoming resistant to it in one or two doses. The company would never consider working for it's approval, but when refractory patients were given the IMGN drug and became refractory to it, they were no longer refractory to the SOC products they'd been on, often for years. I certainly don't know, but it's possible patients could be kept alive indefinitely by using the SOC until they're refractory, then a dose or two of the Oncolysin, IMGN's drug. There were definitely people in that trial whose lives were extended substantially, but IMGN developed what they believed to be far superior tech. It took perhaps another decade of more before Kadcyla was approved, but rather than wait for their revenue to increase from royalties on growing sales, they monetized it so others earned the revenue as it became a blockbuster drug. Finally they developed Rayaldee which they wholly owned and on success, sold the company. Frankly it made me sick though it was reasonably profitable. ABBV estimated it would be bringing in earnings of $2 billion a year, they stole the company for just over $31 a share. it should have been $40 to $50, or more. Plus they have other drug in their pipeline whos early stage trial data looks good. If I could have taken ABBV shares I'd have done it, but it wasn't an option.
Gary
