NorthWest Biotherapeutics Inc (NWBO)

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In Nature preprint, Dr. Liau did analysis on scRNA-seq.

Dendritic Cell Vaccination in Conjunction with TLR Agonist Polarizes Interferon Immune Responses Associated with Long-term Survival in Malignant Glioma Patients [scRNA-seq]
https://ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE237579

What is scRNA-seq? Here is the answer from ChatGPT.

Single-cell RNA sequencing (scRNA-seq) is a powerful technique used in molecular biology to analyze the gene expression profiles of individual cells within a heterogeneous population. In the context of tumors, scRNA-seq allows researchers to study the complex cellular composition and heterogeneity present within the tumor microenvironment.

Tumors are not homogeneous masses of identical cells but rather consist of various cell types, including cancer cells, immune cells, stromal cells, and others. Each of these cell types may contribute differently to tumor growth, metastasis, and response to therapy.

By using scRNA-seq, researchers can identify and characterize the different cell types present in a tumor, as well as understand their gene expression patterns, interactions, and functional states. This information is crucial for deciphering the mechanisms underlying tumor development, progression, and response to treatment.

Some of the key applications of scRNA-seq in tumor research include:

Cellular Heterogeneity: Revealing the diverse cell populations within tumors and understanding how they contribute to tumor growth, metastasis, and therapy resistance.

Tumor Microenvironment: Characterizing interactions between cancer cells and non-cancerous cells (e.g., immune cells, fibroblasts) in the tumor microenvironment and how these interactions influence tumor progression.

Identification of Biomarkers: Discovering novel biomarkers associated with specific tumor subtypes, disease progression, or response to therapy, which can potentially be used for diagnosis, prognosis, and treatment stratification.

Therapeutic Targets: Identifying new therapeutic targets by pinpointing molecular pathways that are dysregulated in specific cell populations within the tumor.

Drug Resistance Mechanisms: Investigating mechanisms of drug resistance at the single-cell level, which can inform the development of more effective therapeutic strategies.

Overall, scRNA-seq provides a comprehensive and high-resolution view of the cellular landscape within tumors, enabling deeper insights into tumor biology and the development of more personalized and targeted cancer therapies.
3:12 AM · Mar 29, 2024
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