NorthWest Biotherapeutics Inc (NWBO)

[learningcurve2020]

Anyone want to discuss the differences between this "Dual target" T cells approach vs. L's DC "trained" T's?

>>CAR-TEAM cells have a dual targeting mechanism that enables them to attack the cancer cells at two different targets.

In this trial, the first target was a common cancer mutation known as EGRFvlll.

The second target is wild type EGFR, a protein that is not detected in normal brain tissue but is expressed in more than 80 percent of cases of glioblastoma.

https://www.massgeneral.org/cancer-center/news/q-and-a-about-car-t-therapy-for-glioblastoma

>>“That is not something that’s been done a lot historically in an academic medicine setting — basic laboratory research going all the way to clinical trials in patients,” said Maus. “But we’re doing it, and I think it’s really important what you can achieve as a field when you take that approach.”

https://news.harvard.edu/gazette/story/2024/03/novel-teamwork-promising-results-for-glioblastoma-treatment/