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New Research from China
ORIGINAL RESEARCH article
Front. Cardiovasc. Med., 14 March 2024
Sec. Cardiovascular Epidemiology and Prevention
Volume 11 - 2024 | https://doi.org/10.3389/fcvm.2024.1328087
Decreased circulating omega-3 fatty acids increase the risk of myocardial infarction: a two-sample Mendelian randomization study

Wei Wang1,2 Linfei Yang1,2 Jing Zhang1,2 Haiyun Xiang2,3*
1Department of Cardiology, The Second People’s Hospital of Hefei, Hefei, Anhui, China
2Department of Cardiology, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China
3Infant Care Services and Management, Institution of Culture Tourism and Education, Anhui Technical College of Industry and Economy, Hefei, Anhui, China

“In this research, we extracted the summary data from published large genetic studies to detect whether there was a causal relationship between omega-3 fatty acids and the risk for MI by TSMR analysis.”

“study theoretically proved the causal relationship between omega-3 fatty acids and myocardial infarction” in subjects of European ancestry

“Conclusion

This study highlights the potential value of omega-3 fatty acids in reducing the risk of myocardial infarction.”

relevant citations:
References

1. Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med. (2019) 380(1):11–22. doi: 10.1056/NEJMoa181279230415628

42. Mason RP, Libby P, Bhatt DL. Emerging mechanisms of cardiovascular protection for the omega-3 fatty acid eicosapentaenoic acid. Arterioscler Thromb Vasc Biol. (2020) 40(5):1135–47. doi: 10.1161/ATVBAHA.119.31328632212849

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