Biotech Values

[Biowatch]

It’s possible that near famine conditions (i.e., not eating) kicks your metabolism over into being highly efficient, so when you do start eating at a “normal” rate again your body absorbs far more of the calories than it did before and excretes less.

Keep in mind, the weight loss on all these drugs seems to plateau at some point, meaning that your body has adapted to one’s loss of appetite and reduced food intake.

This is something that has used as an explanation for why Hopi Indians and other tribes who live in areas where food is scarce tend to easily become obese when high calorie fast food is cheap and easy to obtain.

The TV show, “The Biggest Loser,” where people compete to lose weight via exercise and vastly cutting back on food intake also tend to have their weight bounce back once they stop the strict regime to “win” on the show.
https://en.wikipedia.org/wiki/The_Biggest_Loser_(American_TV_series)

In 2016, the results of a long-term study by the US National Institute of Health (NIH) were released that documented the weight gain and loss of contestants in Season 8, which aired in 2009.[16] The study found that most of the 16 contestants regained their weight, and in some case gained more than before they entered the contest. Their metabolisms had slowed to the point where they were burning hundreds of calories a day less than other people of their new, reduced size. The New York Times reported: "What shocked the researchers was what happened next: As the years went by and the numbers on the scale climbed, the contestants’ metabolisms did not recover... It was as if their bodies were intensifying their effort to pull the contestants back to their original weight." The article quoted Dr. Michael Rosenbaum who said, "The difficulty in keeping weight off reflects biology, not a pathological lack of willpower."

Your body adjusts to having fewer calories.

Yes, keeping a strict diet will prevent the rebound, but if you don’t think that the magical weight loss can be reversed, it may be hard to realize that you can’t eat as much as you want, or what you used to, when your appetite returns to normal.

IMHO