Anavex Life Sciences Corp (AVXL)

[nidan7500]

tschussmann1: Excellent post, thanks very much for the value added work here. As Xena has said here in the past, " Amyloid growth is a symptom of AD, not the cause". Curious how the FDA still does not get that??? BTW, that's why it is called ..."A CNS-SYSTEM".
https://rapamycintherapy.com/.

My belief is that one can substitute A 2-73 for rapamycin in the text copied below, and see that the ultimate best use of it will be in preventing the early development of Alzheimer's, particularly targeted for APOE4 carriers. Meanwhile, rapamycin is available now.

>>> Alzheimer's disease can be seen as a domino effect. Each domino causes the next domino to fall.
Prevention is based on the prevention of the first few dominoes. Attacking the last few dominoes does not affect prevention. If we consider the pathogenesis as 10 dominoes:
Dominoes 1-3 are the deterioration of the Blood-Brain barrier and deterioration of the cerebral microvascular system.
Dominoes 4,5,6,7 are the failure to maintain myelination in the frontal cortex and associated areas, discussed by Professor George Bartzokis, discussed in his Masterpiece 2011 paper. Bartzokis tragically died in 2014.
Dominoes 8,9,10 are the accumulation of beta-amyloid and hyperphosphorylated Tau. This is a secondary byproduct of failure to maintain myelination. This is the amyloid cascade hypothesis of AD.
Accumulation of amyloid is the result, not the cause of AD. Treatment of dominoes, 8,9,10; has no role in prevention. Dominoes 8,9,10 represent the end-stage pathology of dementia. This is the stage of irreversible brain damage.

[new summary from Dr Green's rapamycin website. https://rapamycintherapy.com/. For those wanting an in depth understanding of Alzheimer's, this site is quite useful in doing so./quote] WGT