NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

Memory lane. Here was my first post on Ihub NWBO message board.

flipper44
Member Level
Re: None
Wednesday, 12/18/2013 5:36:24 PM

Dendritic Cells: Train B, Helper-T and T Cells.

Additionally, antibodies are proteins made by the B cells….



-

- Immature dendritic cells phagocytose pathogens and degrade their proteins into small pieces and upon maturation present those fragments at their cell surface using MHC molecules. Simultaneously, they upregulate cell-surface receptors that act as co-receptors in T-cell activation such as CD80 (B7.1), CD86 (B7.2), and CD40 greatly enhancing their ability to activate T-cells. They also upregulate CCR7, a chemotactic receptor that induces the dendritic cell to travel through the blood stream to the spleen or through the lymphatic system to a lymph node. Here they act as antigen-presenting cells: they activate helper T-cells and killer T-cells as well as B-cells by presenting them with antigens derived from the pathogen, alongside non-antigen specific costimulatory signals
Every helper T-cell is specific to one particular antigen. Only professional antigen-presenting cells (macrophages, B lymphocytes, and dendritic cells) are able to activate a resting helper T-cell when the matching antigen is presented. However, macrophages and B cells can only activate memory T cells[citation needed] whereas dendritic cells can activate both memory and naive T cells, and are the most potent of all the antigen-presenting cells. — Wikipedia --

Good Day.