NorthWest Biotherapeutics Inc (NWBO)

[biosectinvestor]

I disagree.

Initially that may be the case, but they might do a deal where they want to market to particularly important cancers and even perhaps a combination drug/treatment and a company might be able to do a deal with them that the new treatment will be called XYZ. NWBO might handle the manufacturing for DCVax-L, but the final treatment might be branded and marketed under a new name. It might reference DCVax-L in marketing. All kinds of deals can be put together.

As for manufacturing and storage, I do not agree generally with your views on machines. I have always said that NWBO will likely have manufacturing facilities, which may continue to include a CDMO running that facility, to make DCVax-L, but they would never give the machines away or sell them for others to do with them whatever they want, for the DCVax-L production. Their technology is a critical competitive edge. They might license them under severe restrictions much later, so that a purchaser could not make a lysate based vaccine with dendritic cells of violate the license, but the problem with that is they lose IP ultimately because machines are easily backward engineered, once you do that and IP is terrible for any kind of machinery. And also, when you maintain close control of a secret sauce, your IP protection is basically FOREVER. Even when someone steals it from your careful care and protection, like Coke's "recipe", you can sue people for billions of dollars. Once you put it all out there, it's gone. Leasing or selling, it's the same thing. It's not going to happen in my opinion and if they did do it, long-term it's a HUGE mistake given the nature of their technology at base. They are NOT a CDMO, and Advent is simply a contractor. Advent as an inside the tent contractor though is in a special position and it would be better to work with one or only very few CDMOs rather than any and all. Again, trade secrets are extremely powerful ways to protect your IP and they last as long as you maintain the secret, so forever. But if you don't take care to maintain the secret, you lose the protection.

No, I disagree on different vials of cancer. Sure, if they come back for treatment. But if a person has both lung cancer and brain cancer at the same time, say metastatic cancer, but the cancers are different, and if they have surgery, a vaccine would be one batch with different tumors. There's be no reason to do it 2 different times. They are processing antigens, not making a different product.

I think you go too far into the weeds in this next part Gary. Of course they won't likely necessarily hold onto vaccine for decades patients. It costs space, money and capacity. However, if they had a research clause and had a reason to hold onto some portion of it, that would be up to their R&D or even commercialized research arm.