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Re: XenaLives post# 449834

Sunday, 01/28/2024 1:38:18 PM

Sunday, January 28, 2024 1:38:18 PM

Post# of 464820

I haven't read anywhere that Excellence failed....



From AVXL's PR: "This was the very first study of ANAVEX®2-73 in pediatric patients with Rett syndrome. After 12 weeks, the study showed improvement on the key co-primary endpoint Rett Syndrome Behaviour Questionnaire (RSBQ), which is a detailed 45-item questionnaire for assessing multiple Rett syndrome characteristics by the patients’ caregivers. The other co-primary endpoint, the Clinical Global Impression – Improvement scale (CGI-I), which represents a less granular assessment by the site investigators using a seven-point scoring (one=“very much improved” to seven=“very much worse”), was not met."

The failure to meet statistical significance in two co-primary endpoints constitutes a trial failure in my opinion. But you be you by all means.
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