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Tuesday, January 09, 2024 5:39:21 PM
The "very high placebo effect" repost. (A two-fold placebo effect, by the way: both in the patient and in the observer/recorders of outcomes.)
"Steady: "Placebo subjects don't get the drug so how does 2-73 kick it up a notch?"
Answer: Both cohorts (drugged and placebo) will evidence the placebo effect. Our drugged cohort beat the placebo cohort by 50%. My little theory is that the Sigmar1 receptor or chaperone we enhance is actually what's behind placebo effects generally. By kicking up Sigmar1 we are kicking up the mechanism behind placebo effects - which have real bodily effects, its not just perception*.
* Although in this trial, the measurements are subjective and so you get an additional "placebo effect" outside the bodily placebo effects. I could bet the subjective recorders of what they are seeing are also "seeing what they want to see" (positive improvement), try as they might to be objective. So we saw a placebo effect (likely the same in both cohorts) of around 8 points, which is higher than the norm and my thought is maybe 3 points of that is due to the subjective nature of the person recording what they "see".
So, I suppose you could subtract those 3 points from both cohort's improvements. So the placebo group would then show a 5 point improvement and the drugged cohort a 9 point improvement. Which actually would then give us our "statistically significant" improvement number after all !!"
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