NorthWest Biotherapeutics Inc (NWBO)

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Direct controls the tumor microenvironment and directs the ongoing immune response including cytokine production and signaling. Improper spacing of treatments can cause loss of proper signaling as DCs move off site from hypoxic environment which results in a signaling change and immune response suppression as if the battle is over. TREGs come in unhindered then as well as checkpoint response and suppressive myeloid cells. Best wishes.