NorthWest Biotherapeutics Inc (NWBO)

[Lykiri]

Great post flipper44

I was correct that researchers were correct that Temodar slows or inhibits t-cells’ ability to fight cancer.

Even Doctor Roger Stupp acknowleges the limited effectiveness of temozolomide in combination with immunotherapy for GBM patients with MGMT Unmethylated status.

Doctors usually follow surgery with the chemo treatment for glioblastoma, temozolomide. But the tests indicated that Scolyer’s tumor would respond poorly to it.

There was another reason to skip temozolomide: the drug, along with steroids usually given for brain swelling, can impair immune activity and potentially sabotage the benefits of immunotherapy. Even Roger Stupp, the Northwestern University oncologist who pioneered temozolomide’s use in glioblastoma, thought it best to leapfrog the standard protocol.



“You cannot win a Formula 1 race with one foot on the gas pedal, and the other on the brakes,” Stupp said in an emailed response to questions about Scolyer’s case

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https://www.bnnbloomberg.ca/a-doctor-with-brain-cancer-is-helping-transform-its-treatment-1.1984525

Professor Richard Scolyer was diagnosed with GBM MGMT Unmethylated status. (May 2023)