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Re: skitahoe post# 658989

Monday, 12/25/2023 12:05:26 AM

Monday, December 25, 2023 12:05:26 AM

Post# of 699418
Gary, if I recall correctly the word was the trial had been suspended/put on hold as there wasn't funding available to pursue it and the DCvax-L Glioblastoma study at the same time. The company has operated on a financial shoestring for years and they probably couldn't afford a second one. FWIW, and I suspect you have this information already, the trial’s identifier on ClinicalTrials.gov is NCT02982941, but the record has not been updated since January 2017. The original objective was to test the safety and efficacy of DCVax-L and Pembrolizumab in 30 patients with microsatellite stable colorectal cancer that has spread to the liver. The January 2017 update increased the estimated enrollment from 30 to 40 participants. The estimated primary completion date was changed from December 2018 to December 2019, and the estimated study completion date was changed from December 2019 to December 2020. The eligibility criteria were revised to include patients with KRAS wild-type tumors and exclude patients with KRAS mutant tumors, and the study design was updated to include an interim analysis after 20 patients had completed 12 weeks of treatment.
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