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Friday, December 15, 2023 2:05:50 PM
As a biologist and member of the American Association for the Advancement of Science (AAAS) I receive and read each week’s edition of Science, a major science journal. Today’s edition had an article titled “At last, modest headway against Alzheimer’s.”
Of course, all of us await the publication of the promised journal article that will validate blarcamesine’s clinical efficacy in the treatment of Alzheimer’s disease. Each issue of Science has a number of important science research articles, all peer-reviewed, but very unlikely the Anavex paper will appear in Science. Most likely, it will appear in a journal dealing specifically with medical research.
Still, I was interested to learn what Science was posting about “headway against Alzheimer’s.” Inasmuch as Science is the premier American science journal, its readership includes science policymakers at all levels. Anything in the article related to Anavex and it’s molecules?
Nothing specific. The article focused only on the “headway” being made with two monoclonal antibody drugs, noted in this excerpt:
The brains of people with Alzheimer’s hold tangled protein clumps called beta amyloid, and for years scientists debated whether removing them would help patients. Various therapies that did so flopped. But the new treatment, an antiamyloid monoclonal antibody called lecanemab, slowed loss of cognition by 27%, compared with placebo, in a pivotal 18-month trial. It was enough to persuade regulators in the United States and later Japan to approve it. In trial results this summer, another antibody treatment that also targets brain amyloid, called donanemab, slowed cognitive decline by as much as 35% versus placebo in a slightly different patient population, and U.S. approval could come any day. Both therapies are given intravenously.
But unlike the reports from others, the Science author told the whole story:
Although Alzheimer’s researchers, doctors, and patients are celebrating, they’re also eyeing a dark side: the risk of brain swelling and brain hemorrhage from the treatments, which in rare cases has been fatal. People with a gene variant predisposing to Alzheimer’s, called APOE4, are especially prone to this side effect; also potentially at higher risk are people with Alzheimer’s who take drugs to prevent or dissolve blood clots, including those who suffer a stroke and get powerful clot busters as emergency treatment.
How, then, will the Anavex article compare, when it appears somewhere? Won’t be much mention of “brain swelling” or “brain hemorrhage.” And, of course, the Anavex drug will be administered merely by a daily pill; no intravenous procedures.
Recent AVXL News
- Form S-3 - Registration statement under Securities Act of 1933 • Edgar (US Regulatory) • 07/29/2024 09:21:49 PM
- Results from Anavex Life Sciences Landmark Phase IIb/III Trial of Blarcamesine Presented at Alzheimer's Association Conference • GlobeNewswire Inc. • 07/28/2024 09:00:00 PM
- Anavex Life Sciences to Present at the H.C. Wainwright 5th Annual Neuro Perspectives Virtual Conference • GlobeNewswire Inc. • 06/20/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/17/2024 11:30:10 AM
- Anavex Life Sciences Announces Expansion of Leadership Team • GlobeNewswire Inc. • 05/22/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/17/2024 10:01:00 AM
- Anavex Life Sciences to Present at the H.C. Wainwright 2nd BioConnect Investor Conference at NASDAQ • GlobeNewswire Inc. • 05/14/2024 11:30:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) Urged to Join Class Action - Contact The Gross Law Firm to Learn More • PR Newswire (US) • 05/10/2024 09:45:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/09/2024 08:35:55 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/09/2024 12:00:30 PM
- Anavex Life Sciences Reports Fiscal 2024 Second Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 05/09/2024 11:30:00 AM
- The Gross Law Firm Announces the Filing of a Securities Class Action on Behalf of Anavex Life Sciences Corporation(AVXL) Shareholders • PR Newswire (US) • 05/07/2024 09:45:00 AM
- Form DEFA14A - Additional definitive proxy soliciting materials and Rule 14(a)(12) material • Edgar (US Regulatory) • 05/06/2024 10:03:33 AM
- Anavex Life Sciences Corporation Sued for Securities Law Violations - Contact The Gross Law Firm Before May 13, 2024 to Discuss Your Rights - AVXL • PR Newswire (US) • 05/03/2024 09:45:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Second Quarter Financial Results on Thursday, May 9th, 2024 • GlobeNewswire Inc. • 05/02/2024 11:30:00 AM
- May 13, 2024 Deadline: Contact The Gross Law Firm to Join Class Action Suit Against AVXL • PR Newswire (US) • 04/26/2024 09:45:00 AM
- Contact The Gross Law Firm by May 13, 2024 Deadline to Join Class Action Against Anavex Life Sciences Corporation(AVXL) • PR Newswire (US) • 04/19/2024 09:45:00 AM
- The Gross Law Firm Reminds Shareholders of a Lead Plaintiff Deadline of May 13, 2024 in Anavex Life Sciences Lawsuit - AVXL • PR Newswire (US) • 04/16/2024 09:45:00 AM
- Class Action Filed Against Anavex Life Sciences Corporation (AVXL) - May 13, 2024 Deadline to Join - Contact The Gross Law Firm • PR Newswire (US) • 04/12/2024 09:45:00 AM
- Anavex Life Sciences to Present at the Noble Capital Markets Virtual Healthcare Equity Conference • GlobeNewswire Inc. • 04/11/2024 11:30:00 AM
- Class Action Filed Against Anavex Life Sciences Corporation (AVXL) - May 13, 2024 Deadline to Join - Contact The Gross Law Firm • PR Newswire (US) • 04/09/2024 09:45:00 AM
- Anavex Life Sciences Corporation Class Action: The Gross Law Firm Reminds Anavex Life Sciences Investors of the Pending Class Action Lawsuit with a Lead Plaintiff Deadline of May 13, 2024 - AVXL • PR Newswire (US) • 04/05/2024 09:45:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) should contact The Gross Law Firm about pending Class Action - AVXL • PR Newswire (US) • 04/02/2024 09:45:00 AM
- Lost Money on Anavex Life Sciences Corporation(AVXL)? Join Class Action Suit Seeking Recovery - Contact The Gross Law Firm • PR Newswire (US) • 03/29/2024 09:45:00 AM
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