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Sunday, 11/12/2023 3:18:53 PM

Sunday, November 12, 2023 3:18:53 PM

Post# of 34624
They "CLAIM" "newly found ‘kill switch’ (CD95 Fas) triggers death of cancer cells", BUT NOT so newly found as there are articles going back a decade.
https://www.foxnews.com/health/potential-cancer-breakthrough-newly-found-kill-switch-triggers-death-cancer-cells-one-two-punch
the good part: "CD95 receptors — also referred to as Fas — have gained the nickname "death receptors" because they send a signal that causes cancer cells to "self-destruct"".

the BAD part article CLEARLY states: "Despite many breakthroughs in the cancer immunotherapeutic field, targeting Fas remains neglected, primarily due to fear of retaliation against immune-system T-cells,"

From this 2015 article: https://www.nature.com/articles/cdd20153
The "fear of retaliation against immune-system T-cells" (from above) is explained "The tumor strikes back,
It has been demonstrated a number of times that expression of CD95L by apoptosis-resistant tumor cells enables a powerful ‘counterattack’ against antitumor immune effector cells, such as cytotoxic killer cells, many of which are themselves sensitive to CD95L-mediated apoptosis".
And also: "However, given the fact that almost all established cancers express CD95, and the fact that most cancer cells are resistant to apoptosis induction, we would suggest that stimulating CD95 on cancer cells may not be an effective approach to killing cancer cells".

SO, in conclusion: LET'S GO MRKR AND MULTI-TAA.
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