Amarin Corp Plc (AMRN)

[Laurent Maldague]

While we wait, baseline characteristics of BRAVE. No mention of APOE genotyping. Seems like this will be an important subgroup to track.

Participants were primarily non-Hispanic white (125/131;
95%) and male (112/131; 85%) and had a parental history of
dementia (69/131; 57%). Mean age at baseline was 65.8 (7.0)
years. Most participants served in the Army (40%) followed by
the Navy (24%), Air Force (15%) and Marines (11%); 80/131
(61%) went on one or more deployments. The proportion of
participants with a four-year degree, 48/131 (36%), was higher
than the state average of 30%. Although 51% of participants
reported witnessing a traumatic event, none reported having
PTSD symptoms. One in five participants reporting losing
consciousness for more than 1 minute after a blast or crash and
37/131 (28%) reported having a concussion or head injury. The
average total cholesterol was 175.4 mg/dL (43.2 mg/dL) which
is lower than the state average for ages 40-65 (200.2 mg/dL)
and ages >65 (187.1 mg/dL). Self-reported chronic conditions
included high cholesterol (48.5%), high blood pressure (48.5%),
and diabetes (18.9%). The sample was mildly obese, with a
mean BMI and WHR of 30.1 (4.82) and 0.978 (0.07) respectively.
Likewise average blood pressure was slightly elevated (mean
systolic = 136 [16.5], mean diastolic = 82.5 [7.8]). The frequency
of chronic conditions, BMI and blood pressure are broadly in
line with the WI state population. The average MOCA score
at baseline was 25.6 (2.6); 46/131 (35%) of participants fell
below the suggested cut-off of 25 for cognitively unimpaired
participants. Participants with a college degree scored slightly
higher on ADCS-PACC constituent measures: Logical Memory
delayed recall (p=.08), Logical memory immediate recall
(p=.02), digit symbol substitution (p=.02), and Mini Mental
State Exam (p=.02). However, baseline cognitive scores were
unrelated to age, having one or more chronic conditions,
number of deployments, or possible TBI. 116/131 (89%)
participants had a successful LP and 115/131 (89%) participants
had useable MRI scans. Mean total hippocampal volume was
7,941.9 mm3 (844.14). After adjusting for white and gray matter
volume, total hippocampal volume at baseline was unrelated
to age, education level, number of deployments, having one
or more chronic conditions, or possible TBI.

https://www.ctad-alzheimer.com/files/files/JPAD%20CTAD%20abstracts.pdf