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Re: SILVERSURFER4263 post# 22458

Tuesday, 10/03/2023 8:07:18 AM

Tuesday, October 03, 2023 8:07:18 AM

Post# of 26695
Read: https://en.wikipedia.org/wiki/Minocycline (Research)

Early research has found a tentative benefit from minocycline in schizophrenia,[50] with several trials underway.[51] A 2014 meta-analysis found minocycline may reduce negative and total symptom scores and was well tolerated.[52]



Research is examining the possible neuroprotective and anti-inflammatory effects of minocycline against the progression of a group of neurodegenerative disorders including multiple sclerosis, rheumatoid arthritis, Huntington's disease, and Parkinson's disease.[53][54][55][56] As mentioned above, minocycline harms ALS patients.



Citations:

"Preliminary Study Shows Creatine and Minocycline May Warrant Further Study In Parkinson's Disease" (Press release). National Institute of Health. 23 February 2006.
Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, et al. (July 2000). "Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease". Nature Medicine. 6 (7): 797–801. doi:10.1038/77528. PMID 10888929. S2CID 22681391.
Tikka TM, Koistinaho JE (June 2001). "Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia". Journal of Immunology. 166 (12): 7527–7533. doi:10.4049/jimmunol.166.12.7527. PMID 11390507.
Nirmalananthan N, Greensmith L (December 2005). "Amyotrophic lateral sclerosis: recent advances and future therapies". Current Opinion in Neurology. 18 (6): 712–719. doi:10.1097/01.wco.0000187248.21103.c5. PMID 16280684. S2CID 3255995.
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