Anavex Life Sciences Corp (AVXL)

[Steady_T]

I'm going to play devil's advocate on this issue.

I agree that slowing the brain volume reduction appears to be a good thing.

However, an alternative explanation is that 2-73 is causing moderate swelling of the brain resulting is slowing the expected
AD brain volume loss. Do I think that is the case? Not likely, but as a scientist you have to look for all possible explanations for the data.
The FDA will consider that as a possibility. Until there is evidence eliminating that possibility, it is on the table.
AFAIK Anavex has not looked at brain volume in other trials such as PDD or Rett. If there is no evidence of brain swelling in those trials then the possibility can be eliminated.

Science is a slow process because you have to eliminate alternative explanations before coming to a conclusion.

Physicist Richard Feynman once said, “The first principle is that you must not fool yourself, and you are the easiest person to fool.” One way we fool ourselves is by imagining we know more than we do; we think we are experts.