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Re: abew4me post# 431774

Wednesday, 09/20/2023 7:53:34 PM

Wednesday, September 20, 2023 7:53:34 PM

Post# of 463809
The full answer to your question needs to know about how the two primary endpoints met their endpoints.

As I understand it, if both primary endpoints met the P<0.05 standard then choosing the more demanding 0.025 for one endpoint and the secondary endpoint would seem to be more stringent requirement indicating more efficacy.

If one end point didn't make the P<0.05 standard and the other primary endpoint did make the p<0.025 and the secondary made the P<0.025 standard then the results are just as strong i.e. the trial met endpoints.

As I see it, it's like this. Plan A met all endpoints and they chose Plan B which was more demanding to show efficacy. Or Plan A didn't quite make it and Plan B does meet the criterion for success so they went with Plan B.

The real folly is ignoring the progress the company has made.

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