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Re: Hazel2323 post# 430946

Saturday, 09/16/2023 8:16:17 AM

Saturday, September 16, 2023 8:16:17 AM

Post# of 463032
This is a plausible explanation, but it would not be for AA, it would simply be for acceptable FDA filing, AA or not. I wrote to IR for an explanation of the differing mean changes. It could be a change in subpop (eg mITT, which can change the LSM) the type of t-test, etc. If arithmetic mean (instead of LSM) was originally provided by the CRO, that would be a shocking error in judgement. The company should not have left the change unexplained; their disclosure quality needs improvement. But I'm sure Jin is now reviewing all stats, so he might have caught something.

It was good to get clarity around the p-vals. This time around, from the given CIs it's clearly an appropriate 2-tail z-test. All hail Dr Jin.
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