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Higher triglyceride levels are associated with the higher prevalence of layered plaques in non-culprit coronary plaques

Journal of Thrombosis and Thrombolysis, Published: 13 September 2023

Kiyoshi Asakura, Yoshiyasu Minami, Takako Nagata, Masahiro Katamine, Yusuke Muramatsu, Daisuke Kinoshita & Junya Ako

https://link.springer.com/article/10.1007/s11239-023-02888-6

Highlights
+A high TG level was associated with the presence of layered plaques.

+High LDL-C levels and low EPA/AA ratios were associated with the presence of TCFA and macrophages.

+These results showed TG-specific effects on coronary artery plaques.

Univariate and multivariate analyses were performed to identify biomarkers independently associated with vulnerable plaque characteristics. Predictive variables measured in our daily clinical practice and regarded as cardiovascular risk factors were chosen for the multivariate analysis. Namely, we applied LDL-C levels >=140 mg/dL, according to the criteria for dyslipidemia; and eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio<0.4 and high-density lipoprotein cholesterol (HDL-C) levels < 35 mg/dL, as several studies demonstrated an association with clinical outcomes in patients with coronary artery disease [17, 18, 19, 20].

19. Bhatt DL, Steg PG, Miller M et al (2019) Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med 380:11–22. https://doi.org/10.1056/nejmoa1812792