Amarin Corp Plc (AMRN)

[ORBAPU]

“Highly purified extract of fish oil” is a misleading characterization. Extract suggests a fish press, SNL Bass-O’matic, or a centrifuge.

Vascepa is not fish oil, purified or otherwise. Vascepa is Icosapent Ethyl, a derivative of the chemical molecule Eicosapentanoic Acid (EPA), one of the omega 3 polyunsaturated fatty acids. EPA is found in fish oil, algae, and certain plants. Ethyl (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate is a long-chain fatty acid ethyl ester resulting from the formal condensation of the carboxy group of (5Z,8Z,11Z,14Z,17Z)-icosapentaenoic acid with the hydroxy group of ethanol. Icosapent ethyl is de-esterfied, converted into active EPA, and then absorbed in the small intestine. It reaches peak plasma concentration in 5 hours post-oral administration. Very little (<1%) is left circulating in the plasma as EPA incorporates into phospholipids, TG's, and cholesterol esters. Vascepa is 96% or higher purity Icosapent Ethyl. Vascepa is not fish oil, it’s not concentrated fish oil, it’s not distilled fish oil, it’s not highly purified fish oil, it’s not single barrel fish oil, it’s not double oak fish oil.