Okay. But that is an ungrammatical sentence:
"The majority of TEAEs were observed during up-titration of which (light) dizziness... ((ten percent of them))... leading to study discontinuation."
I suppose it was meant to read "...led to study discontinuation"
It's also totally mixed up. Here's what it is trying to say:
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Over 50% of the Treatment Emergent Adverse Events happened as the dose was being increased in patients.
Of that 50+ percent of TEAEs in patients getting increasing dosages that eventually led to them dropping out, 10% of them did so due to a TEAE of dizziness.
(3 percent of placebo dose increasers got really dizzy too, but maybe they were dizzy to begin with!)
Elsewhere it says that some 5% total participants dropped out of the dosed group.
So, it seems (if you continue with the implied math above - and it's fuzzy) that the only adverse effect that amounted to any kind of a whole number seems to be the dizziness effect. And Anavex is saying here that it led to some dropping out as their dose increased. But it may also have been seen in those who stayed in - who knows, they don't say that anywhere, but I'll bet it was the case! And it looks like it didn't effect very many of those dropping out, but it was one side effect that did repeat and stick out apparently, and thus is of some interest to us (or them). And the Aussie investigator noticed it too, but saw it as a sign of the drug's effectiveness. So there you go. Whoopie-do.
