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Friday, 07/21/2023 8:57:30 PM

Friday, July 21, 2023 8:57:30 PM

Post# of 458722
Alberto J Espay @Alberto... 4d
Donanemab in early symptomatic
Alzheimer's disease - Infographic
of the phase 3 trial data published
by JAMA earlier today.
Highlights:
• No improvement
• ~3-point less worsening in iADRS
(below MCID)
• 3.4% slower decline (not 35%!)
@alzforum @alzassociation

Alberto J Espay @Alberto... 4d
We are treating Alzheimer's as if it
were cancer. It isn't. The brain still
shrinks at any level of amyloid
detection, as @Kariem_Ezzat
reminds us. Amyloid is a normal
reaction to pathogens of various
kinds. By shooting the messenger,
we only create the illusion of
success.
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