NorthWest Biotherapeutics Inc (NWBO)

[Umibe5690]

Skitahoe:

I am certainly no expert, but the proliferation of educated T-cells is definitely an important part of the significant effects of DC VAX L. However, it is not the whole story. Of particular importance are the issues of T- cell exhaustion and the immunosuppressive environment. We know that with the mesenchymal signature, the vaccine is more effective because there is a greater residue of T cells upon which an attack on the tumor(s) can be mounted and that the tumor micro environment is less suppressive. Hence a so called “hot” tumor. Cold tumors have a smaller surfeit of T-cells upon which to build and the micro environment is much more suppressive. As a mono therapy, DC VAX L has achieved significant results although less dramatically in unmethylated signatures. Accordingly, with a cocktail approach, adding adjuvants such as poly ICLC, a myeloid inhibitor as well as a CI such as Keytruda, in combination with the keystone DC VAX L, goes a long way in significantly addressing these issues contributing to dramatically increased overall survival, and in a significant number of cases even a possible cure if I may dare to say so, and with an enhanced quality of life. I think this Is truly amazing.

GLTU.