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Re: tredenwater2 post# 420033

Monday, 06/26/2023 3:36:11 PM

Monday, June 26, 2023 3:36:11 PM

Post# of 473050
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Whole blood transcriptomics analysis (RNAseq) was performed for the PDD study at two timepoints: baseline and Week 14. After quality control filtering, 14,150 genes were retained for analysis. Methods: Weighted gene correlation network analysis (WGCNA) was used to identify clusters of genes that show a correlated expression change across patients and timepoints. Thus, a data-driven gene network was generated. Associations between the identified clusters and treatment arms were explored in order to select clusters for which gene expression is significantly associated with the high blarcamesine dose. These associations were assessed using linear mixed effect models with three covariates: dose, patient and timepoint. Significance was assessed with Dunett’s test. Results:



IMO, Dr.M. and team have been working to verify the continuous (not well understood) CNS cellular micro cross-talk functional-nerve -bio links. There has been excellent scholarly work on (all understood) systems by Dr. Peter Senge @MIT school of computer sciences, see his book , "The fifth Discipline", as in Physics, Chemistry, Mathematics...Systems". IMO, CNS is the ...6TH system)Clear links have been established and written about how the CNS has links established for human nerves which act as conducting elements (like tiny wires) over which bacteria (at least ) are proven spread infections of a type (see studies of teeth gum infections as cause for forms of R. Arthritis ). All Dr.M. is doing is peeling the CNS conductor onions he sees as new CNS discovery enabled by S1R bio-links. Connecting the DOTS, so to speak......makes a lot more sense than Amyloid Plaques, and there are no verified contradictions, unlike plaques.

This discovery process could go on for a long time, IMO.

https://www.webmd.com/rheumatoid-arthritis/rheumatoid-arthritis-periodontal-disease#:~:text=Rheumatoid%20arthritis%20(RA)%20and%20gum,the%20inflammation%20found%20in%20RA.
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