NorthWest Biotherapeutics Inc (NWBO)

[hankmanhub]

Think of MHC 1 and 2 proteins as flagpoles that are made inside antigen presenting cells like DCs for this example. Self and foreign antigens (peptides) are taken up via pinocytosis etc after destruction of tumor cells, virus infected cells etc. Then these peptides are loaded as “flags” onto the MHC 1 or 2 flagpoles inside the DC, and then sent to the cell surface for display to T cells (primarily). The T cells then recognize (or not) the “flag” as self or foreign- but the flag must be in the context of either MHC 1 or 2 (I.e. on the flagpole)

"T cells then recognize (or not) the “flag” as self or foreign" -- that is the essence of the question. HOW DO THEY DO THIS?