NorthWest Biotherapeutics Inc (NWBO)

[hankmanhub]

This will result in increasing damage to the DNA which is expressed on the cell surface as increasing numbers of abnormal epitopes / peptides. The increasing damage to the DNA will lead to uncontrolled growth of abnormal cells (ie malignant change). Once this process has started, even if there is only 1 abnormal epitope on each cell, the individual cells are beyond repair and the only way the body can control the situation is to destroy any and all abnormal cells, be there just 1 malignant epitope or hundreds displayed on each cell.

Thank you for your response. But several questions remain. 1) How is the "abnormal" epitope recognized as such? This is where the MHC proteins come into play, but unfortunately I am not clear on the details of how that works. 2) What guarantees that an internal cellular abnormality will always be expressed by a cell surface epitope where it can be recognized?