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Re: delerious1 post# 17390

Friday, 05/19/2023 7:15:48 PM

Friday, May 19, 2023 7:15:48 PM

Post# of 20362
There is a LOT of proof that 3CL Protease Inhibitors work on covid. Paxlovid is THE example. It is great 3CL Pro Inhibitor--it just has another part (Ritonavir) that does not play well with MANY other meds (major DDI). But the Pax website goes into the MOA and chemistry. The Todos website has a chart showing the IC 50 of Ivermectin and Tollovid-TolloVIR and Paxlovid

Shionogi is in a PH III trial with their 3CL Pro Inhib that hopefully is as effective as Pax and without the other issues--but that will be months+ for trial results and possible FDA approve/EUA

The TolloVID is NOT approved to treat covid but it doesn't need EUA because it is a OTC version of 3CL Pro Inhibitor. Todos drug version TolloVIR had great results in a PH II trial in Israel (it was small size) but never had funds to run PH III--which is sad from several ways. They did not receive a EUA either in Israel for TolloVIR which easily could have saved some lives but anecdotal until allowed.

As far as Todos they are 1st to state "not approved to diagnose, treat, prevent or cure ANY disease"--only states 3CL Protease Inhibitor that FDA agrees. But we see Drs that are using for Viral eradication--and writing about TolloVID and talking about its use with patients

There have been people that posted here and DR Dorit Arad has talked about using Tollovid in acute covid but they have learned not to make ANY claims about covid