Anavex Life Sciences Corp (AVXL)

[falconer66a]

Blarcamesine works better and bigger than perceived.

(I actually think there are some other nice benefits we don't know of yet, as Mayo's work hints at.)

I've been contending this since I discovered how blarcamesine actually works; by activating the sigma-1 receptor protein.

When I first learned of Anavex and its molecules, perhaps five years ago or so, the early preclinical trials data were too good to be true; both in humans and murines (lab rodents). Seemed quite improbable that a single small molecule could somehow cause such a diversity of good therapeutic outcomes. And, without endocrine, genomic, immunologic, teratogenic (birth defects) or other side effects typical of strong drugs working in the CNS. At that time the Anavex naysayers stated that there was no mechanism(s) by which the small molecule could yield its detected therapeutic outcomes. At that time the mechanisms of action of the drug were not well known or recognized.

Not so, today. Simply, by its propitious activation of the sigma-1 receptor the receptor can then favorably modulate a diversity of downstream reactions and cell-keeping processes. Simply, Anavex has not yet published all that they know about what blarcamesine is capable of. They know; they've done back-lab studies on lab worms and rodents. Treatment of CNS disorders is just the first thrust of the company. Far more will come --- at the right times, with the right supporting data.