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Re: aesop1 post# 588850

Wednesday, 04/26/2023 5:20:20 PM

Wednesday, April 26, 2023 5:20:20 PM

Post# of 701137
aesop1,

There has been some great discussion about manufacturing this pharmaceutical product at large scale. Capacity to manufacture is crucial and the acquisition of the Flaskworks technology was a brilliant move by the company. Thanks for highlighting these topics. I can’t wait to hear more news about manufacturing DCVax-L.

March 2023 Manufacturing News:



https://cms.mhra.gov.uk/mhra/mia/uk-mia-54923

https://nwbio.com/northwest-biotherapeutics-and-advent-bioservices-announce-receipt-of-license-for-commercial-manufacturing-at-sawston-u-k-facility/




LP said that the UK facility can supply North America, but they will likely use the Memphis facility too depending on money/timing. Either facility should have enough capacity to stand alone, but they could use both.

They have been planning well to build the capacity to address a worldwide demand.

https://p.widencdn.net/ud1zkk/DS-TS-immunology-dendritic-cells-activation-assay







Manufacturing is also crucial when considering the vast possibility of combo therapies and the possibility of treating other cancers beyond GBM.



Don’t miss ASCO 2023!

https://clinicaltrials.gov/ct2/show/NCT04201873



https://brownneurosurgery.com/breakthrough-brain-cancer-vaccine/

https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847
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