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Thursday, April 06, 2023 11:17:30 AM
Re KZR. I posted why I was reducing my position back in Jan . This famous quote comes to mind
When the facts change, I change my mind - what do you do, sir?”
Regarding ARDX and my diarrhea concern . Wife ( who has dialysis patients on phosphorous binders already ) states that most of her patients complain of constipation so it may not be a problem.
She plans on introducing them slowly to the new drug with the existing phosphorous binders they are already on .....and then try and reduce the number of old binders .
Her patients hate these binders anyway and most never get close to an acceptable phosphorous level .
Almost everyone in the trials were willing to power thru the first week of diarrhea issues so that they could get off the old binders ....and she thinks her patients will be the same.
XPHOZAH is not a miracle drug . Not everyone has a major response ....but enough do to make it clinically significant .
Once approved I expect most Nephrologists will want to try it
Question now is ...once the NDA is submitted ( fairly soon probably ) will it be a standard 6 mth review or an expedited 2 mth review.
Kiwi
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