Anavex Life Sciences Corp (AVXL)

[DaveV-1]

Scan costs
Hey Doc, for awareness these are the costs ICER just used in estimating for the recent approvals in Dec 2022:

Monitoring Costs
For the first year while a patient used donanemab or lecanemab, we assumed they were monitored for ARIA using brain magnetic resonance imaging (MRI) every three months. Because evidence suggests the vast majority of ARIA occurs within the first year of treatment, no MRIs were modeled after the first year on treatment. We assumed an average brain MRI cost of $261.10 per scan (HCPCS code 70553).
For donanemab, we modeled a PET scan given every six months while on
the drug to test for complete amyloid clearance. If a patient stopped treatment with donanemab due to achieving complete amyloid clearance, they received a PET scan every year to test amyloid levels if they had not reached moderate AD. We assumed an average amyloid PET scan cost of $4,467.

Adverse Event Costs
In addition to the brain MRIs described above for monitoring, if a patient experienced an ARIA event, the patient received a brain MRI every four weeks until the ARIA was either resolved or stabilized.
The average duration of an ARIA event was 12 weeks; therefore, a patient that
experienced an ARIA event received three additional brain MRIs associated with managing the adverse event. We assumed an average brain MRI cost of $261.10 per scan (HCPCS code 70553).