Anavex Life Sciences Corp (AVXL)

[ALP7]

Thanks for the info. Just started following AVXL last March.

Found the original presentation, http://www.arianapharma.com/wp-content/uploads/2019/07/Anavex-Microbiota-Presentation-AAIC-July-2019-FINAL-1.pdf and https://clinicaltrials.gov/ct2/show/NCT02244541.

Hope that the 2b/3 trial compares placebo with both arms re microbiome differences.

This article, https://academic.oup.com/jambio/article/127/4/954/6715074?login=false, was an interesting review of studies, but I question this statement: "In brief, the present hypothesis accounts for several common questions confronting all major theories of Alzheimer's dementia. One explanation is that there is a relationship between the biology of ageing and the biology of AD in that ageing can increase intestinal inflammation and change bacterial taxa." (I bolded). This statement was also in the Ariana presentation. There have been studies that show that some areas of the world that haven't been exposed to a "western diet" (highly processed foods) have double the microbiome diversity of those who are eating a western diet. Could it be the long term effect of this diet as opposed to ageing?