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Re: plexrec post# 408440

Friday, 03/24/2023 9:04:52 PM

Friday, March 24, 2023 9:04:52 PM

Post# of 462178
Both monoclonal antibodies and Anavex molecules?

Well, the fellow seems competent in being able to assess and understand the several new therapeutic approaches to Parkinson's and Alzheimer's. He mentioned monoclonal antibodies, of course, but didn't specifically mention any agents working at the sigma-1 receptor protein (the Anavex mechanism).

However, I would expect him to mention not only Anavex's sigma-1 receptor activators but to explain in some detail how they work, as ligands of the sigma-1 protein, thereby facilitating or promoting a number of normalizing downstream processes and reaction chains in otherwise diseased neurons. Let's see if he recognizes and explains the Anavex MOAs (mechanisms of action). Those are the real story in new CNS therapies.

Let's see what he talks about.
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