NorthWest Biotherapeutics Inc (NWBO)

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Bright Boy

Member Level
Re: dstock07734 post# 577898

Saturday, March 18, 2023 7:48:14 PM

Post#
577938
of 577960
You're welcome, "D" !!!

I think all of us are beginning to understand the impact of DCVax-L, both on a stand alone basis and in combination with other treatments in treating nGBM and rGBM. The results are astonishing !!!! AND the "Booster" application is truly incredible!!!

I spoke to a brilliant doctor friend of mine, who was educated at Stanford and is very familiar with the DCVax Complex AND asked with all the great potential just revealed by Dr. Marnix Bosch, shouldn't the company "beat the drum", "ring the bell", "shout to the heavens" how great a discovery has been made and he said,"Within permisable limits, they already have when the slide deck was presented by Marnix Bosch and posted on the company website. Further, that the quickest way for a company to run into trouble is to promote and front run the RA's, each of which have a different set of rules and policies and procedures!!

I also spoke to another friend, who is a "Giant" in the financial world and his comment was" Within 12 hours of the release of that slide deck, every executive, in every executive committee in every biotech company in the world had reviewed that slide deck !!! AND some of them have been aware of that data and results for a long time!!! I also asked him about the SP of the company being $.60 on the OTC. He said,"Only fools are influenced by the OTC manipulators!!! If I were still advising big biotech companies, I would tell them to find friendly partners to build a consortium to acquire Northwest, because your company alone is definitely not capable of bidding on a company that has produced these kinds of results with the associated, anticipated, future revenues!!"

So now you know everything I know and if you need any corroborating color, just ask Maverick 1, who is considered by many to be one of the "Greatest Whiz Kids" to ever to walk the streets of Wall Street!!!

And before I sign off, a few words for Dr. Greg Zivic. I've never meant Dr. Zivic, but I know that he is one of the most skilled ER physicians in the country and my best friend, Dr. Steve Ayers, founding member of the ER clinic at Aspen Valley Hospital in Aspen, CO and the 2 of them are from the same mold!!! and are skilled at saving lives when there's no one in the room to turn to and ask" So what should I do next!!!' No time to consult an operating manual or a textbook. They use their skills swiftly and decisively in "Playing the hand they're dealt!!!" One of my favorite quotes from Viet Nam, adjusted for the ER field of battle, perfectly describes these two fine men and thousands of others that are fighting to save the lives of the rest of us when needed:

"We the willing, challenged by the unknowing
Are doing the impossible for the patients
We have done so much for so long with so little
We are now qualified to do almost anything with nothing!!

AND

That quote can be used to describe out team of cancer warriors at Northwest!!!

Bravo to the doctors and physicians that do so much to improve our quality of life and to hell with those that deliberately interfere with their efforts !!!


Cheers,

BB

Bright Boy

Member Level
Re: None

Saturday, March 18, 2023 12:38:55 PM

Post#
577853
of 577961
People, People, People !!!!

The light switch just turned on for me !!! I'm not a doctor or scientist or a STEM concentration "rock star", but if I read something over and over again several times and look carefully at the pictures SOMETIMES, NOT ALL THE TIME, a major mental breakthrough occurs and I believe that I've discovered something very profound!!

In this case, I believe the main message from the slide deck is that DCVax-L, either by itself or in combination with CI's has turned the whole thing around for treating nGBM/rGBM from having to kill the tumor to a "management process" !! It looks like now with this new information, that GBM patients can receive vaccinations as needed with "Zero" side effects and live a long and happy life !!! A comment from a medical expert that DOES KNOW !!!:

Dr. Greg Zivic:

This treatment can turn a Glioblastoma into a chronic treatable disease even after recurrence of the tumor.

So help me out here. Does the above reasoning seem logical based on the slides all of us have just reviewed?? If it does or is, then little Team Northwest has just changed the healthcare landscape forever in the way that we treat disease!!!!!

Am I way off base or are all of onto to something that is fabulous beyond belief???

Cheers,

BB

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MARKETSFINANCIAL REGULATION
First U.S. Trader Convicted of ‘Spoofing’ Gets Three Years
Michael Coscia was first to be criminally prosecuted after bluffing tactic was outlawed by Dodd-Frank
image
Michael Coscia appeared in a Chicago courthouse in October 2015. He subsequently was found guilty and sentenced to three years in prison for using a bluffing tactic called ‘spoofing’ that was made illegal by the Dodd-Frank law.
PHOTO: NANCY STONE/TNS/ZUMA PRESS
By Aruna Viswanatha
July 13, 2016 4:38 pm ET

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The first U.S. trader to be convicted of using a bluffing tactic called “spoofing” after it was made illegal by the Dodd-Frank law was sentenced Wednesday to three years in prison.

Prosecutors had sought a sentence of at least five years and 10 months, while lawyers for the trader, 54-year-old Michael Coscia, had asked for probation. In November, a Chicago jury found him guilty of manipulating commodity futures prices in a scheme that yielded him $1.4 million.

The case against Mr. Coscia, head of futures trading firm Panther Energy Trading LLC, was the first criminal prosecution of a trader for spoofing after it was explicitly outlawed by the 2010 Dodd-Frank financial-overhaul law.

The tactic, which involves entering large orders a trader doesn’t intend to execute to move prices in the trader’s favor, has since come under increased scrutiny from regulators and law enforcement.

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A lawyer for Mr. Coscia, Stephen Senderowitz, said he plans to appeal the verdict on several issues, including whether the Dodd-Frank spoofing provisions are unconstitutionally vague, and plans to ask the court to allow Mr. Coscia to delay his prison term while the appeal is heard.

In a separate spoofing case, a federal judge in Chicago on Tuesday allowed trader Igor Oystacher to continue some limited trading while he awaits trial on civil allegations from the U.S. commodities regulator.

In requesting Mr. Coscia’s sentence, prosecutors said in court documents: “This Court now has the opportunity to send a message, loud and clear, that our financial markets operate on principles of honesty and transparency, and do not allow a select few traders to profit in the trading markets through illegal bait and switch schemes at the expense of other traders.”

Mr. Coscia’s lawyers had countered that the trader had used a single trading strategy over a 10-week period in 2011, which he “immediately stopped using” after exchange regulators notified him of concerns.

At his trial last fall, prosecutors in Chicago argued Mr. Coscia engaged in spoofing in markets for gold, soybean meal, soybean oil, high-grade copper and currency futures.

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Write to Aruna Viswanatha at [e-mail]


biosectinvestor

Member Level
Re: Poor Man - post# 577462

Saturday, March 18, 2023 8:27:39 PM

Post#
577950
of 577961
I did not say it was BASED on criminal allegations. I know exactly what civil litigation is and I know exactly what discovery can reveal. I do expect them to find new things out that will lead to new defendants and they have allowed their systems to be used in a manner that resulted in illegal market manipulation. Civil liability means negligence, but more likely we may find intentionality. If intentionality is involved at the brokers but certainly at their customer level, then I do expect that criminal behavior will be passed along by the civil lawyers to the appropriate law enforcement authorities and hopefully to DOJ or US Atty’s rather than the SEC or CFTC. These people are effectively working to kill people and the punishment should match the crime.

Clearly they do not have the requisite intent to murder anyone. It is a byproduct of their greed and fraudulent behavior. But when people die as a result of criminality, there should be serious consequences, not slaps on the hand for such criminals to go back to what they were doing or for their employers to go back to it. That kind of liability travels up the chain of responsibility to officers of the company, even if it is simply being fired and disgraced. I spare no sympathy for such people.
Bullish
BULLISH


dstock07734

Member Level
Re: iwasadiver post# 577764

Saturday, March 18, 2023 3:30:20 PM

Post#
577890
of 577962
iwasadiver,

We are all talking about potential possibilities. Merck is certainly one possibility. What NWBO needs most is the capital to do the clinical trials. This should not be a problem once we have the approval. With the new FDA guidance on tissue-agnostic approval, NWBO may not need massive clinical trials on different targets. I simply cannot see why NWBO needs Merck. If there was a secret deal between NWBO and Merck, why did LP hire George Zavoico? It seems to me that Zavoico's responsibility is to maximize the value of NWBO. A buyout from Merck doesn't seem like the one.

The reason I mentioned about Baker Brothers is that they like sharks that can smell a tiny drop of blood miles away. If we can see anything with huge potential, they certainly can smell it too. Keep in mind Felix Baker himself is an expert on immune stuff. His Ph.D. dissertation from Stanford is about T-cell infiltration stuff.
The T cell receptor repertoire of early islet infiltrating T cells in non-obese diabetic (NOD) mice

They used to own Alexion which has C5 inhibitors (Soliris) for PNH, one of the top 10 most expensive drugs. Soliris has to be IV administered. Baker Brothers were the largest shareholder. He sold it to AZN for $39b as more effective and oral inhibitors show potential in clinical trials. They own about 30% of Seagen. They must smell thing more lucrative. Otherwise they could not have sold it to Pfizer. They also invested in bio techs using immunotherapy to cure cancer. Why NWBO cannot be their investment option?

https://www.drugs.com/slideshow/top-10-most-expensive-drugs-1274

We are talking a lot about the combo trial of DCvax-L + Keytruda. IMO, we should talk a lot about this paper, which has super exiting information. From the paper, we can see that why DCVax-L is the center of the immnotherapy universe. Without it, those inhibitors just would not work. The combination of DCVax-L + Poly-ICLC + Pd-1 inhibitor + CSF-1Ri may very well be the cure for cancers. Simplify look at the survival percent in the animal model. For DCVax-L + Keytruda, the survival percentage in animal model over 80 days is 12.5% which transforms 60% patients living over 700 days in human trial. What would happen to human trial if the number is 50% in animal model? Pardon me for redecorating the graph with thick red line out of excitement.

https://academic.oup.com/neuro-oncology/article/19/6/796/2927952