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ANAVEX2-73 (blarcamesine) is a sigma-1 receptor (S1R) agonist with a strong safety record and preliminary efficacy evidence in patients with Alzheimer's disease and Rett syndrome, other synaptic neurodegenerative and neurodevelopmental disorders. S1R's role in calcium homeostasis and mitochondrial function, cellular functions related to synaptic function, makes blarcamesine a potential drug candidate for FXS.

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https://www.yahoo.com/news/covid-cause-heart-problems-heres-150000401.html

When a person is infected with Covid, the immune system launches a hefty inflammatory response in an effort to fight off the virus. That inflammation, the new study found, disrupts how calcium is stored in the heart.

Calcium ions — a version of the element that carry a positive charge — are important messengers that regulate heart function, including how quickly and how forcefully the organ contracts. These ions are stored inside cells, on deck for when the body needs to use them. They’re released through channels in the cellular membrane, which ensures that just the right amount of calcium can get out.

The damage caused by inflammation during a Covid infection appears to prop these channels open, letting too much calcium leak from the cells of the heart, said Dr. Andrew Marks, a cardiologist and biophysics professor at Columbia University who co-led the study. This flood of calcium, he said, can decrease heart function and even cause fatal arrhythmias, or irregular heartbeats.

Although inflammation of the heart is a rare but documented side effect of the mRNA Covid vaccines, the study looked only at heart tissue from autopsies before vaccines were available.

“Whatever changes we saw were because of infection,” Marks said, adding that the new study was small, and the next step was to conduct the research on a larger scale.

Calcium also plays an important role in the brain

The findings built on something Marks and his team had observed earlier in the pandemic when they were investigating how Covid affects another organ: the brain.

In a study published in 2021 in the journal Alzheimer’s and Dementia, the team found the same cellular damage to calcium ion channels in autopsied brain tissue of people who had been infected with Covid. These changes, Marks noted, had long been seen in people with Alzheimer’s disease.

Dr. Siddharth Singh, clinical director of the post-Covid-19 cardiology clinic at the Smidt Heart Institute at Cedars-Sinai Medical Center in Los Angeles, said the latest findings help explain the heart and brain problems seen in Covid patients.

“Calcium is an essential mineral for life,” said Singh, who was not involved with the research.

“This may put things together for the heart and the brain.”

Viral infections causing inflammation of the heart is not a new finding.

“Before Covid came onto the scene, during the winter, when viral infections would spike, we would see more people presenting with things like myocarditis,” said Singh, referring to inflammation of the heart lining.

He said the damage wasn’t necessarily permanent. “Over time, symptoms like brain fog and palpitations do get better in some patients, so to an extent, this damage appears to be able to heal,” he said, adding that patients need to be studied longer for researchers to understand exactly what factors allow this to happen.

Dr. Nicholas Hendren, a cardiologist at UT Southwestern Medical Center in Dallas, said: “Once this is better understood, we may be able to develop therapies to treat this damage and potentially a therapy to protect the heart and cardiovascular system from damage from Covid.” Hendren was also not involved in the new research.